N-[(2S,3S,5S)-2-[(3S,5S,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(3S,5S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3S,5R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(2S,3S,5S)-2-[(3S,5S,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(3S,5S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3S,5R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
• 化学式: C₂₆H₄₅NO₂₁
• 分子量: 707.6
• InChiKey: IEQCXFNWPAHHQR-LGEVSZSUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.5
• 重原子数：
  48
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  357
• 氢给体数：
  14
• 氢受体数：
  21

文献信息

• [EN] TERNARY MIXTURES OF 6'-SL, LNnT and LST c<br/>[FR] MÉLANGES TERNAIRES DE 6'-SL, LNNT ET LSTC
  申请人：GLYCOM AS

  公开号：WO2016199071A1

  公开（公告）日：2016-12-15

  A mixture of human milk oligosaccharides that consists essentially of 6'-SL, LNnT and LSTc, made by treating 6'-SL and LNnT in the presence of an α2,6-transsialidase.

  这是一种由人乳寡糖混合物组成的物质，主要由6'-SL、LNnT和LSTc构成，是通过在α2,6-转移酶的存在下处理6'-SL和LNnT制成的。
• METHOD FOR GENERATING HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF
  申请人：Dekany Gyula

  公开号：US20140234912A1

  公开（公告）日：2014-08-21

  A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).

  一种生成人乳寡糖（HMO）或其前体的方法，该方法包括以下步骤：a）提供至少一种来自公式5至10中的化合物组的供体；b）提供至少一种来自乳糖、LNT、LNnT及其衍生物组的受体；c）提供至少一种具有转床苷酶活性和/或糖合成酶活性的酶；d）制备在步骤a）、b）和c）中提供的至少一种供体、至少一种受体和至少一种酶的混合物；e）孵育根据步骤d）制备的混合物。该方法所得到的化合物，以及使用该化合物的组合物和用途也包括在内。
• POLYMORPH OF A TETRASACCHARIDE CONTAINING NACETYL-LACTOSAMINE
  申请人：Glycom A/S

  公开号：EP3241836A1

  公开（公告）日：2017-11-08

  The present invention relates to a new polymorphic form of the tetrasaccharide of formula (I) and the preperation thereof.

  本发明涉及一种新的式 (I) 四糖多晶型及其制备方法。
• A METHOD FOR PREPARATION OF THE TETRASACCHARIDE LACTO-N-NEOTETRAOSE (LNNT) CONTAINING N-ACETYLLACTOSAMINE
  申请人：Glycom A/S

  公开号：EP2536737B1

  公开（公告）日：2017-05-31
• DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF
  申请人：Dekany Gyula

  公开号：US20140212930A1

  公开（公告）日：2014-07-31

  A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises a) providing at least one compound or a mixture of the compounds selected from the group consisting of: optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof; b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b).