[7-hydroperoxy-4-(3-hydroperoxypropyl)-4-methylheptyl] N-[6-[4-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutanoylamino]hexyl]carbamate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [7-hydroperoxy-4-(3-hydroperoxypropyl)-4-methylheptyl] N-[6-[4-[3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutanoylamino]hexyl]carbamate
• 化学式: C₃₀H₅₇N₃O₁₃
• 分子量: 667.8
• InChiKey: QROXCTLUTBKHQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  46
• 可旋转键数：
  27
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  235
• 氢给体数：
  8
• 氢受体数：
  13

文献信息

• [EN] SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT<br/>[FR] ARNSI DE SERPINA1 : COMPOSITIONS ET MÉTHODES DE TRAITEMENT
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2012178033A2

  公开（公告）日：2012-12-27

  The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Serpina1 gene, and methods of using such dsRNA compositions to inhibit expression of Serpina1.
• [EN] PCSK9 iRNA COMPOSITIONS AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS D'ARNI DE PCSK9 ET MÉTHODES D'UTILISATION ASSOCIÉES
  申请人：ALNYLAM PHARMACEUTICALS

  公开号：WO2014089313A1

  公开（公告）日：2014-06-12

  The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the PCSK9 gene, and methods of using such RNAi agents to inhibit expression of PCSK9 and methods of treating subjects having a lipid disorder, such as a hyperlipidemia.