1-Hydroxy-2-(methylamino)pentan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Hydroxy-2-(methylamino)pentan-3-one
• 英文别名: 1-hydroxy-2-(methylamino)pentan-3-one
• 化学式: C₆H₁₃NO₂
• 分子量: 131.17
• InChiKey: UCCUPWLHTKOZHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
  申请人：KYOWA HAKKO KIRIN CO., LTD.

  公开号：US20150299214A1

  公开（公告）日：2015-10-22

  The present invention provides a heterocyclic compound represented by the following formula (I), wherein X A represents CH and the like, R 1 represents cycloalkyl optionally having substituent(s) and the like, L represents a bond and the like, Y A represents —NH— and the like, R 2 represents a hydrogen atom and the like, R 3A represents the following formula (R 3A -1) (wherein, R 3 represents hydroxy and the like) and the like, and R 4A represents the following formula (R 4A -1) (wherein, R 4 and R 5 are the same or different and each represents a hydrogen atom and the like) and the like, or a pharmaceutically acceptable salt thereof, which is useful as a prophylactic and/or therapeutic agent for skin diseases and the like, and the like.

  本发明提供一种杂环化合物，其化学式表示为（I），其中XA代表CH等，R1代表环烷基，可选地具有取代基等，L代表键等，YA代表—NH—等，R2代表氢原子等，R3A代表下式（R3A-1）（其中，R3代表羟基等）等，R4A代表下式（R4A-1）（其中，R4和R5相同或不同，且每个代表氢原子等）等，或其药学上可接受的盐，其作为预防和/或治疗皮肤疾病等的药物具有用途。
• US9701689B2
  申请人：——

  公开号：US9701689B2

  公开（公告）日：2017-07-11
• [EN] COMPOUNDS USEFUL IN THE TREATENT AND/OR CARE OF THE SKIN, HAIR AND/OR MUCOUS MEMBRANES AND THEIR COSMETIC OR PHARMACEUTICAL COMPOSITIONS<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT ET/OU LE SOIN DE LA PEAU, DES CHEVEUX ET/OU DES MUQUEUSES ET COMPOSITIONS COSMÉTIQUES OU PHARMACEUTIQUES ASSOCIÉES
  申请人：LIPOTEC SA

  公开号：WO2014086785A1

  公开（公告）日：2014-06-12

  Compounds of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2; their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, and in processes of treatment and/or care of the skin, hair and/or mucous membranes, in particular in the aging and photoaging of the skin.