Oxonorbornadiene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Oxonorbornadiene
• 英文别名: bicyclo[2.2.1]hepta-1(6),4-dien-2-one
• 化学式: C₇H₆O
• 分子量: 106.12
• InChiKey: CUHKVFZQDYKLSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Batrachotoxin Analogues, Compositions, Uses, and Preparation Thereof
  申请人：Du Bois Justin

  公开号：US20140171410A1

  公开（公告）日：2014-06-19

  Compounds relating to batrachotoxin are provided, in particular analogues that modulate the activity of sodium channels. Also provided are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier, including vehicles that modulate transdermal permeation of the compound. The subject compounds are useful in treatments, including treatments to reduce neuronal activity or to bring about muscular relaxation. The compounds also find use in the treatment of subjects suffering from a voltage-gated sodium channel-enhanced ailment or from pain. Further methods are provided for the preparation of the batrachotoxin-related compounds.

  提供了与蝙蝠毒素相关的化合物，特别是能够调节钠通道活性的类似物。还提供了包含本发明化合物的药物组合物以及药用辅料，包括能够调节化合物经皮渗透的载体。所述化合物可用于治疗，包括用于减少神经活动或引起肌肉松弛的治疗。这些化合物还用于治疗患有电压门控钠通道增强病症或疼痛的患者。还提供了用于制备与蝙蝠毒素相关化合物的方法。
• [EN] HIGHLY SENSITIVE DETECTION OF BIOMOLECULES USING PROXIMITY INDUCED BIOORTHOGONAL REACTIONS<br/>[FR] DÉTECTION HAUTEMENT SENSIBLE DE BIOMOLÉCULES PAR DES RÉACTIONS BIOORTHOGONALES INDUITES PAR LA PROXIMITÉ
  申请人：UNIV CALIFORNIA

  公开号：WO2016109733A1

  公开（公告）日：2016-07-07

  There provided, inter alia, reagents and methods for modulation fluorescence of a tetrazine containing compound and/or a dienophile-containing compound. There is provided a method of detecting binding of a first affinity ligand and a second affinity ligand, the method includes the follow steps. Contacting a tetrazine-containing compound with a dienophile-containing compound, the tetrazine-containing compound comprising a first affinity ligand covalently attached to a tetrazine moiety and the dienophile-containing comprising a second affinity ligand covalently attached to a dienophile moiety.

  提供了用于调节含有四氮杂环的化合物和/或含有二烯丙基的化合物荧光的试剂和方法。提供了一种检测第一亲和配体和第二亲和配体结合的方法，该方法包括以下步骤。将含有四氮杂环的化合物与含有二烯丙基的化合物接触，其中含有四氮杂环的化合物包括与四氮杂环基团共价连接的第一亲和配体，含有二烯丙基的化合物包括与二烯丙基团共价连接的第二亲和配体。
• HIGHLY SENSITIVE DETECTION OF BIOMOLECULES USING PROXIMITY INDUCED BIOORTHOGONAL REACTIONS
  申请人：The Regents of the University of California

  公开号：US20180244643A1

  公开（公告）日：2018-08-30

  There provided, inter alia, reagents and methods for modulation fluorescence of a tetrazine containing compound and/or a dienophile-containing compound. There is provided a method of detecting binding of a first affmity ligand and a second affinity ligand, the method includes the follow steps. Contacting a tetrazine-containing compound with a dienophile-containing compound, the tetrazine-containing compound comprising a first affinity ligand covalently attached to a tetrazine moiety and the dienophile-containing comprising a second affmity ligand covalently attached to a dienophile moiety.
• US9090627B2
  申请人：——

  公开号：US9090627B2

  公开（公告）日：2015-07-28