(R,R)-2,6-bis(4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridine | 790673-84-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R,R)-2,6-bis(4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridine
• 英文别名: (4R)-4-methyl-2-[6-[(4R)-4-methyl-5-oxo-4-propan-2-yl-1H-imidazol-2-yl]pyridin-2-yl]-4-propan-2-yl-1H-imidazol-5-one
• CAS: 790673-84-6
• 化学式: C₁₉H₂₅N₅O₂
• 分子量: 355.44
• InChiKey: ZCEWXNXDSVBUBA-RTBURBONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  95.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 (R,R)-2,6-bis(4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridine 在 potassium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以46%的产率得到(R,R)-2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2yl)pyridine
  参考文献：
  名称：

  New chiral ligands and iron(III) complexes based on 2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridines

  摘要：

  New ligands and their complexes with iron(III) chloride have been suggested and prepared: (R,S)-, (R,R)- and (S,S)-2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl) pyridines. Both the ligands and their complexes were characterised by H-1 and C-13 NMR spectroscopy, optical rotation and X-ray diffraction. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.08.085
• 作为产物：
  描述：

  (2R)-2-氨基-2,3-二甲基-丁酰胺 在 sodium methylate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 24.0h， 生成 (R,R)-2,6-bis(4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridine
  参考文献：
  名称：

  New chiral ligands and iron(III) complexes based on 2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridines

  摘要：

  New ligands and their complexes with iron(III) chloride have been suggested and prepared: (R,S)-, (R,R)- and (S,S)-2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl) pyridines. Both the ligands and their complexes were characterised by H-1 and C-13 NMR spectroscopy, optical rotation and X-ray diffraction. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.08.085

文献信息

• New chiral ligands and iron(III) complexes based on 2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl)pyridines
  作者：Miloš Sedlák、Pavel Drabina、Ivana Císařová、Aleš Růžička、Jiří Hanusek、Vladimír Macháček

  DOI：10.1016/j.tetlet.2004.08.085

  日期：2004.10

  New ligands and their complexes with iron(III) chloride have been suggested and prepared: (R,S)-, (R,R)- and (S,S)-2,6-bis(1-benzyl-4-isopropyl-4-methyl-4,5-dihydro-1H-imidazol-5-on-2-yl) pyridines. Both the ligands and their complexes were characterised by H-1 and C-13 NMR spectroscopy, optical rotation and X-ray diffraction. (C) 2004 Elsevier Ltd. All rights reserved.