1-Galloyl-ss-glucose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Galloyl-ss-glucose
• 英文别名: [(2S,3R,4S,5S,6R)-2,3,4,5-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]-(3,4,5-trihydroxyphenyl)methanone
• 化学式: C₁₃H₁₆O₁₀
• 分子量: 332.26
• InChiKey: UDTRRVKIDSNNJD-KWTDZHAOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  188
• 氢给体数：
  8
• 氢受体数：
  10

文献信息

• INHIBITION OF ANDROGEN RECEPTOR BY EXTRACTS OF MEDICINAL HERBS AND COMPOSITIONS THEREOF
  申请人：YALE UNIVERSITY

  公开号：US20200376067A1

  公开（公告）日：2020-12-03

  In one embodiment, the present invention is directed to a composition comprising an aqueous or ethanolic extract of at least one herb selected from the group consisting of Aloe barbadensis ( :F3), Rheum palmatum L. ( :B6), Stephania tetrandra ( :C4), Phellodendron chinense Schneid. ( :D8), Euphorbia humifusa ( :S6), Eclipta prostrata ( :I2), A. venetum L. ( :F1), Portulaca oleracea L. ( :F5), and Sanguisorba officinalis L. ( :E5), Camellia sinensis var. assamica (Mast.) Kitamura ( :PE) and Punica granatum . ( :PG), and mixtures thereof. The composition is administered to a patient, in an effective amount, in a method of treating, inhibiting, preventing, reducing the incidence of, ameliorating or resolving a disease state or condition caused in part or exacerbated by hyperactivity of the androgen receptor (AR), by inhibiting the androgen receptor protein. These compositions may also be used inhibit or stabilize hair loss or grow hair in a subject in need.
• [EN] TANNIN DERIVATIVE AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID TANNIN DERIVATIVE<br/>[FR] DÉRIVÉ DE TANNIN ET COMPOSITIONS PHARMACEUTIQUES COMPRENANT LEDIT DÉRIVÉ DE TANNIN
  申请人：SANDOZ AG

  公开号：WO2014090832A1

  公开（公告）日：2014-06-19

  The invention concerns a tannin derivative, in particular tannin derivative having antibiotic activity, obtained by covalent coupling of at least one organic acid with at least one tannin, the covalent coupling is formed as an ester or ether bond, and wherein the acid residue provides at least one functional group for covalently coupling at least one pharmaceutically active ingredient, a pharmaceutical composition comprising or consisting of said tannin derivative and a method for producing said tannin derivatives.