9-[(2R,4R,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,3,4-trihydroxyoxolan-2-yl]-2-methyl-1H-purin-6-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-[(2R,4R,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,3,4-trihydroxyoxolan-2-yl]-2-methyl-1H-purin-6-one
• 英文别名: 9-[(2R,4R,5R)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-3,3,4-trihydroxyoxolan-2-yl]-2-methyl-1H-purin-6-one
• 化学式: C₁₅H₂₃N₄O₅P
• 分子量: 370.34
• InChiKey: JXDFIURBQYIPCU-GLXFQSAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140171485A1

  公开（公告）日：2014-06-19

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES ENCODING CITED4
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140186432A1

  公开（公告）日：2014-07-03

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR TREATING ARYLSULFATASE A PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140206755A1

  公开（公告）日：2014-07-24

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR TREATING GALACTOSYLCERAMIDASE PROTEIN DEFICIENCY
  申请人：Moderna Therapeutics, Inc.

  公开号：US20140221465A1

  公开（公告）日：2014-08-07

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES
  申请人：Moderna Therapeutics, Inc.

  公开号：US20150064235A1

  公开（公告）日：2015-03-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.