1-(2-methoxy-phenyl)-2-methyl-1H-indole | 914222-35-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(2-methoxy-phenyl)-2-methyl-1H-indole
• 英文别名: 1-(2-Methoxyphenyl)-2-methylindole
• CAS: 914222-35-8
• 化学式: C₁₆H₁₅NO
• 分子量: 237.301
• InChiKey: MXLMVWKIQOOCRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-bromo-2-(2,2-dibromo-cyclopropyl)benzene 在 potassium tert-butylate 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 2-(二叔丁基膦)联苯 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 2.0h， 生成 1-(2-methoxy-phenyl)-2-methyl-1H-indole
  参考文献：
  名称：

  Palladium-Catalyzed Tandem Allenyl and Aryl C–N Bond Formation: Efficient Access to N-Functionalized Multisubstituted Indoles

  摘要：

  An efficient palladium-catalyzed synthesis of N-functionalized multisubstituted indoles from easily accessible ortho-haloarylallenes and primary amines has been developed. A wide range of electronically and structurally varied nitrogen fragments could be introduced through this tandem C-N bond-forming process by tuning the reaction conditions.

  DOI：

  10.1021/ol3018775

文献信息

• Palladium-Catalyzed Tandem Allenyl and Aryl C–N Bond Formation: Efficient Access to <i>N</i>-Functionalized Multisubstituted Indoles
  作者：Bingxin Liu、Xiaohu Hong、Dong Yan、Shuguang Xu、Xiaomei Huang、Bin Xu

  DOI：10.1021/ol3018775

  日期：2012.9.7

  An efficient palladium-catalyzed synthesis of N-functionalized multisubstituted indoles from easily accessible ortho-haloarylallenes and primary amines has been developed. A wide range of electronically and structurally varied nitrogen fragments could be introduced through this tandem C-N bond-forming process by tuning the reaction conditions.