5-(1H-pyrazol-5-yloxy)-1H-pyrazole

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(1H-pyrazol-5-yloxy)-1H-pyrazole
• 化学式: C₆H₆N₄O
• 分子量: 150.14
• InChiKey: KTLQNAWHRKEQML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF
  申请人：MEDIVATION TECHNOLOGIES, INC.

  公开号：US20140179668A1

  公开（公告）日：2014-06-26

  Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.

  提供了融合嘧啶化合物作为激酶抑制剂，如多激酶抑制剂。提供了融合嘧啶化合物作为IGF-IR抑制剂。这些化合物可用于治疗癌症的方法。还提供了含有融合嘧啶化合物和药用载体的药物组合物，以及含有融合嘧啶化合物或其盐和使用说明的试剂盒，例如用于治疗癌症的方法。
• US9422267B2
  申请人：——

  公开号：US9422267B2

  公开（公告）日：2016-08-23
• US9499519B2
  申请人：——

  公开号：US9499519B2

  公开（公告）日：2016-11-22
• [EN] FUSED PYRIMIDINE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS PYRIMIDINE FUSIONNÉS ET LEUR UTILISATION
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2014105958A2

  公开（公告）日：2014-07-03

  Fused pyrimidine compounds as kinase inhibitors, such as multi-kinase inhibitors, are provided. Fused pyrimidine compounds as IGF-IR inhibitors are provided. Fused pyrimidine compounds that are inhibitors of Trk receptors (e.g., Trk A, Trk B and Trk C) are provided also. The compounds may be used in a method of treating cancer. Pharmaceutical compositions containing a fused pyrimidine compound and a pharmaceutically acceptable carrier are also provided, as are kits containing a fused pyrimidine compound or salt thereof and instructions for use, e.g., in a method of treating cancer.