methyl-[(3R,5S)-5-methyl-6-oxooxan-3-yl]carbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: methyl-[(3R,5S)-5-methyl-6-oxooxan-3-yl]carbamic acid
• 化学式: C₈H₁₃NO₄
• 分子量: 187.19
• InChiKey: OYSJENURBACBLT-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20150307512A1

  公开（公告）日：2015-10-29

  The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.

  本发明提供了FR901464的新型类似物，以及一种改进的制备FR901464及其类似物的方法。这些化合物表现出抗癌活性，是治疗与RNA剪接功能障碍相关的多种疾病状态的候选药物。
• US9771377B2
  申请人：——

  公开号：US9771377B2

  公开（公告）日：2017-09-26
• [EN] SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY<br/>[FR] SYNTHÈSE DE FR901464 ET DE SES ANALOGUES À ACTIVITÉ ANTITUMORALE
  申请人：UNIV PITTSBURGH

  公开号：WO2014100367A1

  公开（公告）日：2014-06-26

  The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.