(2S,3R,4S,5R)-6-acetamido-2,3,4,5-tetrahydroxy-6-oxohexanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,5R)-6-acetamido-2,3,4,5-tetrahydroxy-6-oxohexanoic acid
• 化学式: C₈H₁₃NO₈
• 分子量: 251.19
• InChiKey: KYDADMUFOHPGHO-KCDKBNATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  164
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• A POLYVALENT COMBINED IMMUNISING AND/OR THERAPEUTIC PREPARATION FOR USE IN BACTERIAL INFECTIONS OR FOOD POISONING, PARTICULARLY SALMONELLOSIS, A METHOD FOR PRODUCTION OF THIS PREPARATION, ITS USE AND A VACCINE COMPRISING THIS PREPARATION
  申请人：Zaklad Badawczo-Wdrozeniowy Osrodka Salmonella "Immunolab" Sp. z o.o.

  公开号：EP2934580A1

  公开（公告）日：2015-10-28
• [EN] A POLYVALENT COMBINED IMMUNISING AND/OR THERAPEUTIC PREPARATION FOR USE IN BACTERIAL INFECTIONS OR FOOD POISONING, PARTICULARLY SALMONELLOSIS, A METHOD FOR PRODUCTION OF THIS PREPARATION, ITS USE AND A VACCINE COMPRISING THIS PREPARATION<br/>[FR] PRÉPARATION POLYVALENTE COMBINÉE D'IMMUNISATION ET/OU DE THÉRAPIE POUR UTILISATION LORS D'INFECTIONS BACTÉRIENNES OU D'INTOXICATIONS ALIMENTAIRES, PARTICULIÈREMENT ASSOCIÉES À LA SALMONELLOSE, PROCÉDÉ DE PRODUCTION DE CETTE PRÉPARATION, SON UTILISATION ET VACCIN COMPRENANT CETTE PRÉPARATION
  申请人：ZAKŁAD BADAWCZO WDROŻENIOWY OŚRODKA SALMONELLA IMMUNOLAB SP Z O O

  公开号：WO2014097154A1

  公开（公告）日：2014-06-26

  The invention relates to a polyvalent, combined immunising and/or therapeutic preparation for use in bacterial infections and food poisoning, particularly salmonellosis, comprising inactivated Salmonella sp. strain with antibodies bound thereto, characterized in that the said antibodies are selected so as to bind to the antigenic epitopes in structures of repeating O- specific units in the basic groups of Salmonella bacteria, which are responsible for the principle of reaction with the host immune system, while not blocking the epitopes responsible for the recognition of Salmonella serotype, wherein the inactivated bacteria are bacteria of the Salmonella genus enterica species, subspecies: enterica, salamae, arizonae and/or diarizonae, houtenae, Indica. The invention relates also to a method for production of this polyvalent, combined immunising and/or therapeutic preparation and a vaccine against salmonelloses comprising said preparation.