1-[6-Hydroxy-4-(2-hydroxyethyl)-6-methylcyclohexa-2,4-dien-1-yl]propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[6-Hydroxy-4-(2-hydroxyethyl)-6-methylcyclohexa-2,4-dien-1-yl]propan-1-one
• 英文别名: 1-[6-hydroxy-4-(2-hydroxyethyl)-6-methylcyclohexa-2,4-dien-1-yl]propan-1-one
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.27
• InChiKey: ZTMGCIZYWJEWOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• FIBROIN-CONTAINING HYDROGELS FOR PELVIC TISSUE TREATMENT
  申请人：AMS Research Corporation

  公开号：EP2934380A1

  公开（公告）日：2015-10-28
• [EN] FIBROIN-CONTAINING HYDROGELS FOR PELVIC TISSUE TREATMENT<br/>[FR] HYDROGELS CONTENANT DE LA FIBROÏNE DESTINÉS AU TRAITEMENT DU TISSU PELVIEN
  申请人：AMS RES CORP

  公开号：WO2014100666A1

  公开（公告）日：2014-06-26

  The disclosure provides compositions, systems, and methods for the treatment of pelvic tissue conditions that include use of a silk fibroin-containing hydrogel composition. The composition includes water-soluble fibroin and a water-soluble crosslinkable polymer. The composition can be used as a pre-formed hydrogel or can be delivered to a pelvic tissue site and crosslinked in situ to form a hydrogel. The composition can be used to promote tissue closure, such as vaginal wound or fistula closure. The composition can also be used to enhance attachment or anchoring of a pelvic implant to a pelvic tissue. A hydrogel delivered to a pelvic tissue site, or formed at the site in situ, is associated with a portion of the implant (e.g., a mesh implant) via a tether or implant extension portion, thereby providing improved immobilization of the implant. Systems or kits that include the composition and a delivery needle or insertion tool are also described.