(5R)-6-(azidomethyl)oxane-2,3,4,5-tetrol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5R)-6-(azidomethyl)oxane-2,3,4,5-tetrol
• 化学式: C6H11N3O5
• 分子量: 205.17
• InChiKey: CMLRUUHRGSJVMD-AAILESKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  105
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• CONJUGATES OF A GLYCOPROTEIN OR A GLYCAN WITH A TOXIC PAYLOAD
  申请人：GLYKOS FINLAND OY

  公开号：US20160106860A1

  公开（公告）日：2016-04-21

  The invention relates to a glycoprotein-toxic payload molecule conjugate, a toxic payload molecule-glycan conjugate, and a pharmaceutical composition. The invention further relates to a method for preparing the glycoprotein-toxic payload molecule conjugate, the method for modulating growth of a cell population and a method of treating tumour cells.

  本发明涉及一种糖蛋白-毒素荷载分子结合物、毒素荷载分子-糖基结合物和制药组合物。本发明还涉及一种制备糖蛋白-毒素荷载分子结合物的方法，一种调节细胞种群生长的方法和一种治疗肿瘤细胞的方法。
• LINKER-PAYLOAD MOLECULE CONJUGATES
  申请人：GLYKOS FINLAND OY

  公开号：US20150314007A1

  公开（公告）日：2015-11-05

  The invention relates to novel linker-payload molecule conjugates. The invention also relates to novel cell binder-linker-payload molecule conjugates, in particular antibody conjugates of dolastatin or auristatin derivatives.
• GLYCOENGINEERED ANTIBODY, ANTIBODY-CONJUGATE AND METHODS FOR THEIR PREPARATION
  申请人：SYNAFFIX B.V.

  公开号：US20160257764A1

  公开（公告）日：2016-09-08

  The invention relates to glycoengineered antibodies and antibody-conjugates. In particular, the invention relates to an antibody conjugate, prepared from an IgG antibody comprising one N-linked glycosylation site on the combination of a single heavy chain and single light chain, wherein the N-linked glycosylation site is a mutant N-linked glycosylation site as compared to its wild type counterpart. The invention further relates to methods for the preparation of the antibody-conjugates according to the invention.
• [EN] LINKER-PAYLOAD MOLECULE CONJUGATES<br/>[FR] CONJUGUÉS CONSTITUÉS DE MOLÉCULES DE CHARGE UTILE ET DE LIEURS
  申请人：GLYKOS FINLAND OY

  公开号：WO2014096551A1

  公开（公告）日：2014-06-26

  The invention relates to novel linker-payload molecule conjugates. The invention also relates to novel cell binder-linker-payload molecule conjugates, in particular antibdy conjugates of dolastatin or auristatin derivatives.
• [EN] GLYCOENGINEERED ANTIBODY, ANTIBODY-CONJUGATE AND METHODS FOR THEIR PREPARATION<br/>[FR] ANTICORPS GLYCOMANIPULÉ, CONJUGUÉ D'ANTICORPS ET PROCÉDÉS POUR LEUR PRÉPARATION
  申请人：SYNAFFIX BV

  公开号：WO2015057065A1

  公开（公告）日：2015-04-23

  The invention relates to glycoengineered antibodies and antibody-conjugates. In particular, the invention relates to an antibody conjugate, prepared from IgG antibody comprising at least two N-linked glycosylation sites on the combination of a single heavy chain and single light chain. The invention further relates to methods for the preparation of the antibody- conjugates according to the invention.In particular, the invention relates to an antibody-drug conjugate that is conjugated to different toxins, and the a process for the preparation thereof.