(1S)-1-[3-[(1Z,2S,4aR,8aS)-7-cyano-2,5,5,8a-tetramethyl-6-oxo-1-(2-oxopropylidene)-4,4a-dihydro-3H-naphthalen-2-yl]-3-methylbutyl]-2,4,4-trimethyl-N-(2,2,2-trifluoroethyl)cyclohexane-1-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S)-1-[3-[(1Z,2S,4aR,8aS)-7-cyano-2,5,5,8a-tetramethyl-6-oxo-1-(2-oxopropylidene)-4,4a-dihydro-3H-naphthalen-2-yl]-3-methylbutyl]-2,4,4-trimethyl-N-(2,2,2-trifluoroethyl)cyclohexane-1-carboxamide
• 化学式: C₃₅H₅₁F₃N₂O₃
• 分子量: 604.8
• InChiKey: BRCQBLGJUCLKEC-FRBJBIBESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  87
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ANTIOXIDANT INFLAMMATION MODULATORS: OLEANOLIC ACID DERIVATIVES WITH SATURATION IN THE C-RING
  申请人：REATA PHARMACEUTICALS, INC.

  公开号：US20140179928A1

  公开（公告）日：2014-06-26

  This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
• Compositions and Methods of Treatment of Corneal Endothelium Disorders
  申请人：The Schepens Eye Research Institute, Inc.

  公开号：US20160175380A1

  公开（公告）日：2016-06-23

  This application discloses pharmaceutical compositions (e.g., oral, parenteral or topical ophthalmic formulations) for treating Fuchs endothelial corneal dystrophy (FECD) with one or more Nrf2 activators and/or mitochondrially targeted antioxidants. The compositions may be topically administered to the eye and are effective in the treatment of FECD. The invention further provides methods of treating FECD by in a subject in need of such treatment by topical application of one or more Nrf2 activators and/or mitochondrially of the invention.
• US9090574B2
  申请人：——

  公开号：US9090574B2

  公开（公告）日：2015-07-28
• US9757359B2
  申请人：——

  公开号：US9757359B2

  公开（公告）日：2017-09-12
• USRE45325E1
  申请人：——

  公开号：USRE45325E1

  公开（公告）日：2015-01-06