4-(2,2,2-Trifluoroethylidene)cyclohexa-2,5-dien-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2,2,2-Trifluoroethylidene)cyclohexa-2,5-dien-1-one
• 英文别名: 4-(2,2,2-trifluoroethylidene)cyclohexa-2,5-dien-1-one
• 化学式: C₈H₅F₃O
• 分子量: 174.12
• InChiKey: KKCSNBAMZLUODM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• USE OF CHELATORS OF DIVALENT CATIONS TO PROMOTE NERVE REGENERATION
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20140179741A1

  公开（公告）日：2014-06-26

  Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.

  本文揭示了一种促进神经元轴突生长的方法，包括将有效量的螯合剂与神经元接触，从而促进神经元的轴突生长。还揭示了治疗中枢神经系统损伤的方法，包括向受试者施用治疗有效量的螯合剂。还揭示了促进受损神经元再生的装置和制剂，其中包括经局部给药制备的治疗有效量的螯合剂。提供了这种螯合剂的示例。