[(2R,3S,4R)-3,4-dihydroxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3S,4R)-3,4-dihydroxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₁₀H₁₅N₂O₉P
• 分子量: 338.21
• InChiKey: VORAOZTXNOXTGQ-XDTPYFJJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING DOLICHYL-PHOSPHATE (UDP-N-ACETYLGLUCOSAMINE) N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE 1 (GLCNAC-1-P TRANSFERASE) PROTEIN DEFICIENCY
  申请人：Moderna Therapeutics, Inc.

  公开号：US20140179771A1

  公开（公告）日：2014-06-26

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE TREATMENT OF OTIC DISEASES AND CONDITIONS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150050354A1

  公开（公告）日：2015-02-19

  The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides in the treatment, prevention and/or amelioration of otic diseases or conditions.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160114011A1

  公开（公告）日：2016-04-28

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160348099A1

  公开（公告）日：2016-12-01

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160375134A1

  公开（公告）日：2016-12-29

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.