(12Z,15Z)-1-(dimethylamino)-19-methyl-2-[(9Z,12Z)-octadeca-9,12-dienoxy]icosa-12,15-dien-4-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (12Z,15Z)-1-(dimethylamino)-19-methyl-2-[(9Z,12Z)-octadeca-9,12-dienoxy]icosa-12,15-dien-4-one
• 化学式: C₄₁H₇₅NO₂
• 分子量: 614.0
• InChiKey: ZIXDMGXHEBADMT-LHBJFUQSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.6
• 重原子数：
  44
• 可旋转键数：
  33
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA
  申请人：Protiva Biotherapeutics Inc.

  公开号：EP2281041B1

  公开（公告）日：2014-07-02
• COMPOSITIONS FOR TRANSFECTING RESISTANT CELL TYPES
  申请人：Precision Nanosystems Inc

  公开号：EP3519578B1

  公开（公告）日：2021-12-22
• Compositions for Transfecting Resistant Cell Types
  申请人：Precision NanoSystems Inc.

  公开号：US20210284998A1

  公开（公告）日：2021-09-16

  A transfection reagent composition comprising: 30-60 MOL % of an cationic lipid, or pharmaceutical acceptable salt thereof; 10-60 MOL % structural lipid; a sterol and 0.1 to about 10 MOL % of a stabilizing agent is provided. The reagent is particularly adapted for neuron and related cell types. A method of manufacturing LNP including nucleic acid for selective uptake into either neurons or astrocytes or neural progenitor cells is also provided.