N'-[(2S,5S)-5-[(S)-[(3R)-1-(2-acetylhydrazinyl)-3-[(2R,5R)-6-[[(2S,5S)-5-amino-3-aminooxy-4-(hydroxyamino)-6-(nitrosomethyl)oxan-2-yl]oxymethyl]-3-aminooxy-4-[(2S,5R)-3,4-diaminooxy-6-(aminooxymethyl)-5-hydroxyoxan-2-yl]oxy-5-(hydroxyamino)oxan-2-yl]oxy-2-(aminooxymethyl)-4-nitrosocyclobutyl]-hydroxymethoxy]-6-(aminooxymethyl)-4-(hydroxyamino)-2-methyloxan-3-yl]acetohydrazide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N'-[(2S,5S)-5-[(S)-[(3R)-1-(2-acetylhydrazinyl)-3-[(2R,5R)-6-[[(2S,5S)-5-amino-3-aminooxy-4-(hydroxyamino)-6-(nitrosomethyl)oxan-2-yl]oxymethyl]-3-aminooxy-4-[(2S,5R)-3,4-diaminooxy-6-(aminooxymethyl)-5-hydroxyoxan-2-yl]oxy-5-(hydroxyamino)oxan-2-yl]oxy-2-(aminooxymethyl)-4-nitrosocyclobutyl]-hydroxymethoxy]-6-(aminooxymethyl)-4-(hydroxyamino)-2-methyloxan-3-yl]acetohydrazide
• 化学式: C₃₅H₇₁N₁₇O₂₄
• 分子量: 1114.0
• InChiKey: HPBKBJNVSUPZNY-QKQHSWKTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10.9
• 重原子数：
  76
• 可旋转键数：
  28
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  625
• 氢给体数：
  20
• 氢受体数：
  39

文献信息

• GLYCOSYLATED POLYPEPTIDE AND DRUG COMPOSITION CONTAINING SAID POLYPEPTIDE
  申请人：Glytech, Inc.

  公开号：EP2752424A1

  公开（公告）日：2014-07-09

  [Problem] To provide a glycosylated polypeptide having an affinity to somatostatin receptors, and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least one amino acid in a somatostatin or an analogue thereof being replaced with a glycosylated amino acid.

  [问题]提供一种糖基化多肽，该多肽对体生长抑素受体具有亲和力，并且与体生长抑素相比，具有更好的血中稳定性。 [解决方案]糖基化多肽的特点是，体生长抑素或其类似物中的至少一个氨基酸被糖基化氨基酸取代。