(2S)-3-hydroxy-2-[[(3S)-3-(methylamino)-2-oxobutyl]amino]propanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S)-3-hydroxy-2-[[(3S)-3-(methylamino)-2-oxobutyl]amino]propanal
• 化学式: C₈H₁₆N₂O₃
• 分子量: 188.22
• InChiKey: VWLPJPMINOKEMS-NKWVEPMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• GLYCOSYLATED POLYPEPTIDE AND DRUG COMPOSITION CONTAINING SAID POLYPEPTIDE
  申请人：Glytech, Inc.

  公开号：EP2752424A1

  公开（公告）日：2014-07-09

  [Problem] To provide a glycosylated polypeptide having an affinity to somatostatin receptors, and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least one amino acid in a somatostatin or an analogue thereof being replaced with a glycosylated amino acid.

  [问题]提供一种糖基化多肽，该多肽对体生长抑素受体具有亲和力，并且与体生长抑素相比，具有更好的血中稳定性。 [解决方案]糖基化多肽的特点是，体生长抑素或其类似物中的至少一个氨基酸被糖基化氨基酸取代。
• [EN] AMINO DIACIDS CONTAINING PEPTIDE MODIFIERS<br/>[FR] MODIFICATEURS PEPTIDIQUES CONTENANT DES DIACIDES AMINÉS
  申请人：CHEMICAL & BIOPHARMACEUTICAL LAB OF PATRAS S A

  公开号：WO2015028966A2

  公开（公告）日：2015-03-05

  The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula 1 in the synthesis of peptide derivatives.