3-[2-[[3-[2-[2-[2-[(1S,2R)-2-hydroxy-1-[(3S)-1,3,4-trihydroxybutan-2-yl]oxypropoxy]ethoxy]ethoxy]ethylamino]-3-oxopropoxy]methyl]-2-methyl-3-[3-oxo-3-[2-[2-[2-[(2S,3R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]propoxy]propoxy]-N-[2-[2-[2-[(2S,3R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethyl]propanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[2-[[3-[2-[2-[2-[(1S,2R)-2-hydroxy-1-[(3S)-1,3,4-trihydroxybutan-2-yl]oxypropoxy]ethoxy]ethoxy]ethylamino]-3-oxopropoxy]methyl]-2-methyl-3-[3-oxo-3-[2-[2-[2-[(2S,3R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]propoxy]propoxy]-N-[2-[2-[2-[(2S,3R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethyl]propanamide
• 化学式: C₅₁H₉₇N₃O₃₀
• 分子量: 1232.3
• InChiKey: PSCWMKCUNUSGSV-KICLJTGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.6
• 重原子数：
  84
• 可旋转键数：
  53
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  469
• 氢给体数：
  15
• 氢受体数：
  30

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF TMPRSS6 GENE
  申请人：Bumcrot David

  公开号：US20140194489A1

  公开（公告）日：2014-07-10

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the TMPRSS6 gene, and methods of using such dsRNA compositions to inhibit expression of TMPRSS6.
• SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20140350071A1

  公开（公告）日：2014-11-27

  The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.
• Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20160333342A1

  公开（公告）日：2016-11-17

  The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
• US9175290B2
  申请人：——

  公开号：US9175290B2

  公开（公告）日：2015-11-03