[1-[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylbutan-2-yl]oxy-(2-hydroxybutan-2-yl)phosphinic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [1-[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]-2-methylbutan-2-yl]oxy-(2-hydroxybutan-2-yl)phosphinic acid
• 化学式: C₁₉H₃₁N₄O₇P
• 分子量: 458.4
• InChiKey: VCKSARYPFSJMRU-VUYKINPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  173
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140193482A1

  公开（公告）日：2014-07-10

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160022840A1

  公开（公告）日：2016-01-28

  The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF MEMBRANE PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160289674A1

  公开（公告）日：2016-10-06

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US9233141B2
  申请人：——

  公开号：US9233141B2

  公开（公告）日：2016-01-12