2-Ethoxy-6-[(3-thionitrosopyrazol-1-yl)methyl]pyridine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Ethoxy-6-[(3-thionitrosopyrazol-1-yl)methyl]pyridine
• 英文别名: 2-ethoxy-6-[(3-thionitrosopyrazol-1-yl)methyl]pyridine
• 化学式: C₁₁H₁₂N₄OS
• 分子量: 248.31
• InChiKey: VFXXDQDQGHKPFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  84.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150307485A1

  公开（公告）日：2015-10-29

  A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR 5 ; or X is C and Y is S; Z is selected from N and CH; R 1 is selected from H and C 1-2 alkyl; R 2 is selected from H, C 1-2 alkyl, OH, —CH 2 OH and C 1-2 alkoxy; Each R 3 is independently selected from OH, C 1-3 alkyl, F, Cl, Br, NH 2 , and C 1-3 alkoxy; R 4 is selected from C 1-3 alkyl and haloC 1-3 alkyl; R 5 is selected from H, C 1-3 alkyl and haloC 1-3 alkyl; R 6 and R 7 are either i) each independently selected from H, C 1-3 alkyl and C 1-3 alkoxy; or ii) R 6 and R 7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and R A is selected from H and C 1-3 alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

  化合物式(I)或其药学上可接受的盐：其中：Het是5到10个成员的杂环芳基环；X为N且Y为CR5；或X为C且Y为S；Z从N和CH中选择；R1从H和C1-2烷基中选择；R2从H，C1-2烷基，OH，—CH2OH和C1-2烷氧基中选择；每个R3独立地从OH，C1-3烷基，F，Cl，Br，NH2和C1-3烷氧基中选择；R4从C1-3烷基和haloC1-3烷基中选择；R5从H，C1-3烷基和haloC1-3烷基中选择；R6和R7要么i）各自独立地从H，C1-3烷基和C1-3烷氧基中选择；或ii）R6和R7与它们所附着的环一起形成一个9成员的双环；p为0-3；RA从H和C1-3烷基中选择，提供了含有它们的组合物、它们在治疗中的使用，例如在结核病的治疗中，以及制备这种化合物的方法。
• US8779153B2
  申请人：——

  公开号：US8779153B2

  公开（公告）日：2014-07-15
• US9334265B2
  申请人：——

  公开号：US9334265B2

  公开（公告）日：2016-05-10