3-[1-(2-Dicyclohexylphosphanylnaphthalen-1-yl)naphthalen-2-yl]oxyaniline

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[1-(2-Dicyclohexylphosphanylnaphthalen-1-yl)naphthalen-2-yl]oxyaniline
• 英文别名: 3-[1-(2-dicyclohexylphosphanylnaphthalen-1-yl)naphthalen-2-yl]oxyaniline
• 化学式: C₃₈H₄₀NOP
• 分子量: 557.7
• InChiKey: AFRWZNVPFQRUJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PALLADIUM-CATALYZED ASYMMETRIC (HETERO)ARYLATION AND VINYLATION OF KETONE ENOLATES TO PRODUCE TERTIARY STEREOCENTERS AT ALPHA(α)-POSITION<br/>[FR] (HÉTÉRO)ARYLATION ET VINYLATION ASYMÉTRIQUES D'ÉNOLATES DE CÉTONES CATALYSÉES AU PALLADIUM PERMETTANT DE PRODUIRE DES STÉRÉOCENTRES TERTIAIRES EN POSITION ALPHA(&Agr;)
  申请人：NANAYNG TECHNOLOGICAL UNIVERSITY

  公开号：WO2014109712A1

  公开（公告）日：2014-07-17

  The invention relates to new ligands that are used in a palladium source catalyst system and in palladium catalyzed method for asymmetric α-(hetero)arylation and a-vinylation of ketones. The invention further relates to a process for preparing an asymmetric α-(hetero)arylated or a-vinylated ketone which comprises reacting the tin enolate of the ketone in the presence of catalyst system comprising a ligand of the invention and palladium source. By means of the ligands and process of the invention a stereogenic center in position a of the ketone is established with high enantiomeric excess.