(2R,3S,5S)-2-[(6-ethenylpyridin-3-yl)methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,5S)-2-[(6-ethenylpyridin-3-yl)methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₁₄H₁₉NO₆
• 分子量: 297.3
• InChiKey: XHQSEJHLKCVEDG-LNNYQDNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  112
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• FUNCTIONALIZING REAGENTS AND THEIR USES
  申请人：Glythera Limited

  公开号：US20140364586A1

  公开（公告）日：2014-12-11

  Reagents and methods for functionalizing polypeptides with moieties (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalizing reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalizing reagent is covalently linked to a poly(alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly(alkylene glycol) molecule and/or the glycan group.

  本文披露了一种功能化试剂和方法，用于将（烷基二醇）分子和糖基与多肽功能化。该方法基于一种功能化试剂，该试剂包含一个含氮杂环芳香环，具有一个乙烯基取代基，能够与多肽中天然存在或已引入的一个或多个巯基反应，例如使用一个或多个半胱氨酸残基的巯基。功能化试剂与多（烷基二醇）分子（例如聚乙二醇（PEG）分子）或糖基共价连接，因此，多肽中乙烯基和巯基之间的反应将多肽共价连接到多（烷基二醇）分子和/或糖基上。
• Thiol-functionalising reagents and their uses
  申请人：Glythera Limited

  公开号：EP2886132A1

  公开（公告）日：2015-06-24

  Reagents and methods for functionalising polypeptides with moieties poly(alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalising reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalising reagent is covalently linked to a poly(alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly(alkylene glycol) molecule and/or the glycan group.

  本发明公开了用聚(烷二醇)分子和聚糖基团使多肽功能化的试剂和方法，这些试剂和方法基于一种功能化试剂，该试剂包括一个含氮杂环芳香环，该芳香环具有乙烯基取代基，能够与多肽中天然存在或引入的一个或多个硫醇基反应，例如通过使用一个或多个半胱氨酸残基的硫醇基。官能化试剂与聚(烷二醇)分子（如聚乙二醇（PEG）分子）或聚糖基团共价连接，使乙烯基与多肽中的硫醇基团反应，将多肽与聚(烷二醇)分子和/或聚糖基团共价连接。
• THIOL-FUNCTIONALISING REAGENTS AND THEIR USES
  申请人：Glythera Limited

  公开号：EP2373675B1

  公开（公告）日：2015-10-21
• US8785595B2
  申请人：——

  公开号：US8785595B2

  公开（公告）日：2014-07-22
• US9212148B2
  申请人：——

  公开号：US9212148B2

  公开（公告）日：2015-12-15