(2R,4R,5R)-2-[(4-amino-3-nitropyridin-2-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,4R,5R)-2-[(4-amino-3-nitropyridin-2-yl)amino]-5-(hydroxymethyl)oxolane-3,4-diol
• 化学式: C10H14N4O6
• 分子量: 286.24
• InChiKey: UIOZDHIUNOQPFQ-BHEYDSLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  167
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Inhibition of Nonsense Mediated mRNA Decay by Drugs that Prevent Hypusination of Eukaryotic Initiation Factor 5A
  申请人：Pe'ery Tsafi

  公开号：US20140206637A1

  公开（公告）日：2014-07-24

  Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
• INHIBITION OF NONSENSE MEDIATED MRNA DECAY BY DRUGS THAT PREVENT HYPUSINATION OF EUKARYOTIC INITIATION FACTOR 5A
  申请人：Pe'ery Tsafi

  公开号：US20170319612A9

  公开（公告）日：2017-11-09

  Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
• US9849146B2
  申请人：——

  公开号：US9849146B2

  公开（公告）日：2017-12-26