3-[(2S,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-2-methylidene-3H-pyridine-6-thione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[(2S,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-2-methylidene-3H-pyridine-6-thione
• 英文别名: 3-[(2S,3R,4S,5R)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-2-methylidene-3H-pyridine-6-thione
• 化学式: C₁₅H₂₄NO₃PS
• 分子量: 329.4
• InChiKey: CQIXWGCWDRWNKH-TYVYPOSISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  93.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING ARYLSULFATASE A PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140206755A1

  公开（公告）日：2014-07-24

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160354492A1

  公开（公告）日：2016-12-08

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.