3-chloro-5-[5-chloro-1-(2H-indazol-3-ylmethyl)indazol-4-yl]oxybenzonitrile

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-chloro-5-[5-chloro-1-(2H-indazol-3-ylmethyl)indazol-4-yl]oxybenzonitrile
• 化学式: C₂₂H₁₃Cl₂N₅O
• 分子量: 434.3
• InChiKey: UUOUOYDMUITXEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• USE OF INORGANIC MATRIX AND ORGANIC POLYMER COMBINATIONS FOR PREPARING STABLE AMORPHOUS DISPERSIONS
  申请人：Higgins John

  公开号：US20140206717A1

  公开（公告）日：2014-07-24

  The present invention relates to methods for processing pharmaceutically active substances having poor water solubility in the presence of an inorganic matrix, e.g., magnesium aluminometasilicate, and a secondary polymer as a means of converting the crystalline API to substantially amorphous and stable form, i.e., the crystallinity is less than 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared to typical amorphization or literature methods.