(2R,3S,4S,5R)-2-(hydroxymethyl)-6-[[3-[2-(methylamino)ethyl]-1H-indol-5-yl]oxy]oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5R)-2-(hydroxymethyl)-6-[[3-[2-(methylamino)ethyl]-1H-indol-5-yl]oxy]oxane-3,4,5-triol
• 化学式: C₁₇H₂₄N₂O₆
• 分子量: 352.4
• InChiKey: UXTWWETVBITNLA-VDWCLKJHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  127
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• N-METHYLSEROTONIN AND RELATED SUBSTANCES FOR USE IN TREATING / LESSENING THE OCCURRENCE OF HOT FLASHES RELATED TO MENOPAUSE
  申请人：DSM IP Assets B.V.

  公开号：EP2948159A1

  公开（公告）日：2015-12-02
• MARKETING N-METHYLSEROTONIN AND RELATED SUBSTANCES FOR USE IN TREATING/ LESSENING THE OCCURRENCE OF HOT FLASHES RELATED TO MENOPAUSE
  申请人：DSM IP ASSETS B.V.

  公开号：US20140213536A1

  公开（公告）日：2014-07-31

  Zanthoxylum piperitum (commonly known as Japanese pepper) seeds, including its mature seeds, contain the NMS precursor N-methylserotonin S-O-6-glucoside (“NMS-glucoside”) present in sufficient concentration and are metabolized with sufficient efficiency so as to provide an effective amount of NMS for use in amelioration of menopausal symptoms, including hot flashes/flushes. The Japanese pepper seeds or Japanese pepper seed extracts can also be used to enrich other sources of NMS or NMS precursors in order to provide a nutraceutical or food supplement for controlling hot flashes. This invention relates to the marketing of nutraceuticals and food supplements containing these ingredients. Target customers include perimenopausal women, menopausal women and post menopausal women who wish to reduce the risk of experiencing hot flashes.
• [EN] N-METHYLSEROTONIN AND RELATED SUBSTANCES FOR USE IN TREATING / LESSENING THE OCCURRENCE OF HOT FLASHES RELATED TO MENOPAUSE<br/>[FR] N-MÉTHYLSÉROTONINE ET SUBSTANCES APPARENTÉES POUR LEUR UTILISATION DANS LE TRAITEMENT/LA RÉDUCTION DE L'OCCURRENCE DE BOUFFÉES DE CHALEUR LIÉES À LA MÉNOPAUSE
  申请人：DSM IP ASSETS BV

  公开号：WO2014115113A1

  公开（公告）日：2014-07-31

  Zanthoxylum piperitum (commonly known as Japanese pepper) seeds, including its mature seeds, contain the NMS precursor /V-methylserotonin 5-O-Β-glucoside ("NMS-glucoside") present in sufficient concentration and are metabolized with sufficient efficiency so as to provide an effective amount of NMS for use in amelioration of menopausal symptoms, including hot flashes/flushes. The Japanese pepper seeds or Japanese pepper seed extracts can also be used to enrich other sources of NMS or NMS precursors in order to provide a nutraceutical or food supplement for controlling hot flashes.