1-[4-Azido-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | 84472-85-5

• 物质功能分类: 生物化工 - 核苷类药物 - 脱氧核苷酸及其类似物
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[4-Azido-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 84472-85-5
• 化学式: C9H11N5O4
• 分子量: 253.22
• InChiKey: ZSNNBSPEFVIUDS-UHFFFAOYSA-N

物化性质

• 熔点：
  166-167℃
• 溶解度：
  可溶于DMSO（轻微）、甲醇（非常轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 海关编码：
  2934999090

文献信息

• Modulation of miRNA Activity
  申请人：Miska Eric

  公开号：US20120184457A1

  公开（公告）日：2012-07-19

  Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activity; or (ii) determining the ability of a test compound to alter the binding of a ZCCHC polypeptide to a LIN28 polypeptide, wherein a test compound which alters said binding may be useful in modulating miRNA activity; or (iii) determining the ability of a test compound to bind to a ZCCHC polypeptide, wherein a test compound which binds to the ZCCHC polypeptide may be useful in modulating miRNA activity.
• [EN] MODULATION OF MIRNA ACTIVITY<br/>[FR] MODULATION D'ACTIVITÉ DE L'ARNMI
  申请人：CAMBRIDGE ENTPR LTD

  公开号：WO2011015829A1

  公开（公告）日：2011-02-10

  Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activity; or (ii) determining the ability of a test compound to alter the binding of a ZCCHC polypeptide to a LIN28 polypeptide, wherein a test compound which alters said binding may be useful in modulating miRNA activity; or (iii) determining the ability of a test compound to bind to a ZCCHC polypeptide, wherein a test compound which binds to the ZCCHC polypeptide may be useful in modulating miRNA activity.