Spiro[4.4]non-2-ene-1,4,6,9-tetrone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Spiro[4.4]non-2-ene-1,4,6,9-tetrone
• 英文别名: spiro[4.4]non-2-ene-1,4,6,9-tetrone
• 化学式: C₉H₆O₄
• 分子量: 178.14
• InChiKey: NHNQVCRJECMZLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• HAPTENS OF OLANZIPINE
  申请人：Ortho-Clinical Diagnostics, Inc.

  公开号：US20140213766A1

  公开（公告）日：2014-07-31

  The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzipine. The invention also relates to conjugates of an olanzipine hapten and a protein.

  本发明涉及公式I的化合物，其中R1、R2和R3在说明书中定义，用于合成源自奥氮平的新型结合物和免疫原。本发明还涉及一种奥氮平半抗原和蛋白质的结合物。
• HAPTENS OF QUETIAPINE
  申请人：Ortho-Clinical Diagnostics, Inc.

  公开号：US20140221616A1

  公开（公告）日：2014-08-07

  The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from quetiapine. The invention also relates to conjugates of a quetiapine hapten and a protein.

  本发明涉及式I的化合物，其中R1、R2和R3在说明书中定义，用于合成源自喹硫平的新型共轭物和免疫原。本发明还涉及喹硫平半抗原和蛋白质的共轭物。
• ANTIBODIES TO OLANZAPINE HAPTENS AND USE THEREOF
  申请人：Janssen Pharmaceutica NV

  公开号：US20170343569A1

  公开（公告）日：2017-11-30

  Disclosed is an antibody which binds to olanzapine, which can be used to detect olanzapine in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of olanzapine, including multiplex detection of aripiprazole, olanzapine, quetiapine, and risperidone in a single lateral flow assay device.
• US9303041B2
  申请人：——

  公开号：US9303041B2

  公开（公告）日：2016-04-05
• US9304126B2
  申请人：——

  公开号：US9304126B2

  公开（公告）日：2016-04-05