3-Chloro-5-(4-cyclobutyl-2-fluoro-3-pyrimidin-2-yloxyphenyl)pyrazin-2-amine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Chloro-5-(4-cyclobutyl-2-fluoro-3-pyrimidin-2-yloxyphenyl)pyrazin-2-amine
• 英文别名: 3-chloro-5-(4-cyclobutyl-2-fluoro-3-pyrimidin-2-yloxyphenyl)pyrazin-2-amine
• 化学式: C₁₈H₁₅ClFN₅O
• 分子量: 371.8
• InChiKey: FNVFDRADQOKQNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• FLAP MODULATORS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20140221310A1

  公开（公告）日：2014-08-07

  The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R 1 , L and R 2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

  本发明涉及式（I）化合物，或其形式，其中环A，R1，L和R2如本文所定义，作为FLAP调节剂有用。该发明还涉及包含式（I）化合物的药物组合物。制备和使用式（I）化合物的方法也属于本发明的范围。
• METHOD FOR PRODUCING DENATURED CONJUGATED DIENE POLYMER
  申请人：Morita Hiroyuki

  公开号：US20140221563A1

  公开（公告）日：2014-08-07

  A method for producing a modified conjugated diene polymer usable as a raw material of a crosslinked polymer which is used for use in tires and the like of automobiles and can enhance low fuel consumption performance of automobiles and the like is provided. A method for producing a modified conjugated diene polymer comprising a polymerization step in which a monomer including a conjugated diene compound or a monomer including a conjugated diene compound and an aromatic vinyl compound is polymerized in the presence of at least one compound selected from the group consisting of the following formulae (1) and (2) and an alkali metal compound or an alkaline earth metal compound to obtain a modified conjugated diene polymer. (In the formulae, A 1 is a hydrocarbylsilyl group in which three H's (hydrogen atoms) in a “—SiH 3 ” structure are each substituted by a hydrocarbyl group, and R 1 and R 2 are hydrocarbylene groups.)
• US9090754B2
  申请人：——

  公开号：US9090754B2

  公开（公告）日：2015-07-28
• US9073876B2
  申请人：——

  公开号：US9073876B2

  公开（公告）日：2015-07-07
• US9732093B2
  申请人：——

  公开号：US9732093B2

  公开（公告）日：2017-08-15