N-[(5S)-5-[(2S,5S)-3-acetamido-5-[(1S)-1-[1-[(2S,5S)-3-[(2S,5S)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,5R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxybutan-2-yl]oxy-3-[(2S,5S)-3-[(2S,5S)-3-(2-acetylhydrazinyl)-4-hydroxy-6-(hydroxymethyl)-5-[(2S,5R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxypropoxy]-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(5S)-5-[(2S,5S)-3-acetamido-5-[(1S)-1-[1-[(2S,5S)-3-[(2S,5S)-3-acetamido-4-hydroxy-6-(hydroxymethyl)-5-[(2S,5R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-hydroxybutan-2-yl]oxy-3-[(2S,5S)-3-[(2S,5S)-3-(2-acetylhydrazinyl)-4-hydroxy-6-(hydroxymethyl)-5-[(2S,5R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxypropoxy]-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]acetamide
• 化学式: C₆₄H₁₁₁N₅O₄₅
• 分子量: 1670.6
• InChiKey: JYEZNHAZEUMZJT-AZVMIBPESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -16.3
• 重原子数：
  114
• 可旋转键数：
  35
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  771
• 氢给体数：
  29
• 氢受体数：
  46

文献信息

• GLYCOSYLATED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：Glytech, Inc.

  公开号：EP2762489A1

  公开（公告）日：2014-08-06

  The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon β activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon β activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments.

  本发明的目的是提供一种具有均匀糖链结构、具有干扰素β活性的糖基化多肽。研究发现，具有均匀糖链结构并具有干扰素 β 活性的糖基化多肽可通过以下方法制备：合成糖基化多肽片段和至少两个多肽片段的步骤，以及连接糖基化多肽片段和至少两个多肽片段的步骤。