N-[(5S)-2-[(2R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(5S)-2-[(2R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• 化学式: C₁₅H₂₇NO₁₀
• 分子量: 381.38
• InChiKey: SIJDWCJTRGIRHT-KAMIVGDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  178
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• GLYCOSYLATED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：Glytech, Inc.

  公开号：EP2762489A1

  公开（公告）日：2014-08-06

  The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon β activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon β activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments.

  本发明的目的是提供一种具有均匀糖链结构、具有干扰素β活性的糖基化多肽。研究发现，具有均匀糖链结构并具有干扰素 β 活性的糖基化多肽可通过以下方法制备：合成糖基化多肽片段和至少两个多肽片段的步骤，以及连接糖基化多肽片段和至少两个多肽片段的步骤。