(2S,3S,4R,5R)-2,3,4,5,6-pentahydroxy-2-(2-sulfanylethoxy)hexanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4R,5R)-2,3,4,5,6-pentahydroxy-2-(2-sulfanylethoxy)hexanal
• 化学式: C₈H₁₆O₇S
• 分子量: 256.28
• InChiKey: LNMIAMVWCPLJFD-OOJXKGFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  128
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Nanoparticle delivery compositions
  申请人：Midatech Limited

  公开号：US10300022B2

  公开（公告）日：2019-05-28

  Nanoparticle delivery systems for use in targeting biologically active agents to the central nervous system comprise a composition comprising (a) a nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise a carbohydrate, insulin and/or a glutathione; and (b) the at least one agent to be delivered to the CNS. Methods of treatment and diagnosing CNS disorders utilizing the nanoparticle delivery systems and related screening methods are also disclosed.

  用于将生物活性制剂靶向到中枢神经系统的纳米粒子递送系统包括一种组合物，该组合物包含(a)纳米粒子，该纳米粒子包括：(i)由金属和/或半导体组成的核心；以及(ii)由与核心共价连接的多个配体组成的冠层，其中所述配体包括碳水化合物、胰岛素和/或谷胱甘肽；以及(b)要递送到中枢神经系统的至少一种制剂。还公开了利用纳米颗粒递送系统治疗和诊断中枢神经系统疾病的方法以及相关的筛选方法。
• NANOPARTICLE DELIVERY COMPOSITIONS
  申请人：Midatech Ltd.

  公开号：EP2956119A1

  公开（公告）日：2015-12-23
• [EN] NANOPARTICLE DELIVERY COMPOSITIONS<br/>[FR] COMPOSITION D'ADMINISTRATION DE NANOPARTICULES
  申请人：MIDATECH LTD

  公开号：WO2014125256A1

  公开（公告）日：2014-08-21

  Nanoparticle delivery systems for use in targeting biologically active agents to the central nervous system comprise a composition comprising (a) a nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise a carbohydrate, insulin and/or a glutathione; and (b) the at least one agent to be delivered to the CNS. Methods of treatment and diagnosing CNS disorders utilising the nanoparticle delivery systems and related screening methods are also disclosed.