(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
• 化学式: C15H22ClN7O10P2
• 分子量: 557.78
• InChiKey: SNZJBKKLNDCPHJ-FPKZOZHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.41
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  272
• 氢给体数：
  8
• 氢受体数：
  15

文献信息

• [EN] NANOPARTICLES FOR DRUG DELIVERY<br/>[FR] NANOPARTICULES POUR L'ADMINISTRATION DE MÉDICAMENTS
  申请人：UNIV LOUISVILLE RES FOUND

  公开号：WO2016022845A1

  公开（公告）日：2016-02-11

  The invention provides therapeutic magnetic nanoparticles containing a therapeutic agent connected to a magnetic nanoparticle core through a stable functional group and a linker that can be induced to release the therapeutic agent from the core, through hydrolysis of the functional group. Also provided are methods for making nanoparticles, and methods for using nanoparticles.

  这项发明提供了含有治疗剂的磁性纳米颗粒，该治疗剂通过稳定的功能基团连接到磁性纳米颗粒核心，并且可以通过功能基团的水解诱导释放治疗剂的连接物。还提供了制备纳米颗粒的方法和使用纳米颗粒的方法。
• NANOPARTICLES FOR DRUG DELIVERY
  申请人：KNIPP Ralph J.

  公开号：US20150374849A1

  公开（公告）日：2015-12-31

  The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.

  本发明提供了纳米颗粒、制备纳米颗粒的方法以及使用纳米颗粒的方法。药物输送系统的一个重要属性是其能够允许空间和时间调节药物释放，从而最大限度地减少副作用并提高传统药物的治疗效果。铁氧化物纳米颗粒（NPs），特别是Fe304纳米颗粒，具有许多适当的特性，使它们成为药物输送的可行选择。
• Nanoparticles for drug delivery
  申请人：UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

  公开号：US10342870B2

  公开（公告）日：2019-07-09

  The invention provides therapeutic magnetic nanoparticles containing a therapeutic agent connected to a magnetic nanoparticle core through a stable functional group and a linker that can be induced to release the therapeutic agent from the core, through hydrolysis of the functional group. Also provided are methods for making nanoparticles, and methods for using nanoparticles.

  本发明提供了治疗用磁性纳米粒子，其中含有通过稳定的官能团与磁性纳米粒子磁芯相连的治疗剂，以及可通过水解官能团诱导治疗剂从磁芯中释放的连接剂。此外，还提供了制造纳米粒子的方法和使用纳米粒子的方法。
• US9849193B2
  申请人：——

  公开号：US9849193B2

  公开（公告）日：2017-12-26
• [EN] NANOPARTICLES FOR DRUG DELIVERY<br/>[FR] NANOPARTICULES POUR L'ADMINISTRATION DE MÉDICAMENT
  申请人：UNIV LOUISVILLE RES FOUND

  公开号：WO2014124329A1

  公开（公告）日：2014-08-14

  The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs ), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.