2,2-Dimethyl-1-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]propan-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-Dimethyl-1-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]propan-1-one
• 英文别名: 2,2-dimethyl-1-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]propan-1-one
• 化学式: C₁₇H₂₆N₂O
• 分子量: 274.4
• InChiKey: XICVWWIUYBUKHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS
  申请人：Flynn Gary A.

  公开号：US20140228367A1

  公开（公告）日：2014-08-14

  The present disclosure relates to compounds of the Formula (I): and pharmaceutically acceptable salts, as kinase modulators, compatible with the Type-II inhibition of kinases.

  本公开涉及式（I）的化合物及其药学上可接受的盐，作为酶调节剂，与激酶的II型抑制相兼容。
• Progesterone analogs and uses related thereto
  申请人：EMORY UNIVERSITY

  公开号：US10336787B2

  公开（公告）日：2019-07-02

  This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.

  本公开涉及黄体酮衍生物及其相关用途。在某些实施方案中，本公开涉及本文公开的化合物以及用于控制创伤性脑损伤或中风引起的炎症的用途。
• PROGESTERONE ANALOGS AND USES RELATED THERETO
  申请人：EMORY UNIVERSITY

  公开号：US20190276489A1

  公开（公告）日：2019-09-12

  This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.
• COMPOSITIONS AND METHODS FOR MODULATING T CELL EXHAUSTION
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20210393628A1

  公开（公告）日：2021-12-23

  This invention is in the field of medicinal chemistry. In particular, provided herein are compositions and methods for preventing or reversing T cell exhaustion. In certain embodiments, the present invention relates to methods of preventing or reversing T cell exhaustion by exposing T cells experiencing T cell exhaustion to a new class of small-molecules having a thiazole, imidazolepyridiazine or piperazinyl-methyl-aniline structure, or by expanding genetically engineered T cells in the presence of such small molecules.
• US9221805B2
  申请人：——

  公开号：US9221805B2

  公开（公告）日：2015-12-29