2-(Methylaminomethyl)cyclopent-4-ene-1,3-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Methylaminomethyl)cyclopent-4-ene-1,3-dione
• 英文别名: 2-(methylaminomethyl)cyclopent-4-ene-1,3-dione
• 化学式: C₇H₉NO₂
• 分子量: 139.15
• InChiKey: VJMVEIZLVOKICB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NEMORUBICIN METABOLITE AND ANALOG REAGENTS, ANTIBODY-DRUG CONJUGATES AND METHODS
  申请人：GENENTECH, INC.

  公开号：US20140227299A1

  公开（公告）日：2014-08-14

  The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D) p I where one or more nemorubicin metabolite or analog drug moieties (D) are covalently attached by a linker (L) to an antibody (Ab) which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be useful in methods of diagnosis or treatment of cancer, and other diseases and disorders.