3-Acetyl-1-(4-fluorophenyl)pyridin-2-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Acetyl-1-(4-fluorophenyl)pyridin-2-one
• 英文别名: 3-acetyl-1-(4-fluorophenyl)pyridin-2-one
• 化学式: C₁₃H₁₀FNO₂
• 分子量: 231.22
• InChiKey: QUZNZTIOWRHHQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROTEIN KINASE INHIBITOR CONTAINING PYRROLOPYRIDAZINE DERIVATIVE
  申请人：CJ HEALTHCARE CORPORATION

  公开号：US20160207931A1

  公开（公告）日：2016-07-21

  The present invention relates to a pyrrolopyridazine derivative represented by Formula 1 of the detailed description, or a pharmaceutically acceptable salt thereof. The compound according to the present invention and a pharmaceutically acceptable salt thereof can inhibit the activity of protein kinase(s), and thus are useful for preventing or treating diseases related thereto.

  本发明涉及一种由详细说明中的公式1表示的吡咯吡啶嗪衍生物，或其药用可接受盐。根据本发明的化合物及其药用可接受盐可以抑制蛋白激酶的活性，因此对预防或治疗相关疾病有用。
• PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5-MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS
  申请人：Flynn Gary A.

  公开号：US20140228367A1

  公开（公告）日：2014-08-14

  The present disclosure relates to compounds of the Formula (I): and pharmaceutically acceptable salts, as kinase modulators, compatible with the Type-II inhibition of kinases.

  本公开涉及式（I）的化合物及其药学上可接受的盐，作为酶调节剂，与激酶的II型抑制相兼容。
• NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS
  申请人：BETA PHARMACEUTICALS CO., LTD.

  公开号：US20150315210A1

  公开（公告）日：2015-11-05

  This invention relates to novel fused quinazoline derivatives of Formula I as c-Met inhibitors, their synthesis and uses for treating c-Met mediated disorders.
• US9221805B2
  申请人：——

  公开号：US9221805B2

  公开（公告）日：2015-12-29
• US9242991B2
  申请人：——

  公开号：US9242991B2

  公开（公告）日：2016-01-26