[(2R,4R,5R)-2-[[(3R,4S,6S)-6-[(2S,3S,6S)-5-acetamido-6-[(2R,4S,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-4-hydroxy-5-methyl-6-(1,2,3-trihydroxypropyl)oxan-2-yl] formate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,4R,5R)-2-[[(3R,4S,6S)-6-[(2S,3S,6S)-5-acetamido-6-[(2R,4S,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-4-hydroxy-5-methyl-6-(1,2,3-trihydroxypropyl)oxan-2-yl] formate
• 化学式: C₃₁H₅₃NO₂₂
• 分子量: 791.7
• InChiKey: YSFCQLXZEAEGRQ-ODDNZETJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.1
• 重原子数：
  54
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  363
• 氢给体数：
  13
• 氢受体数：
  22

文献信息

• METHOD FOR PRODUCING PEPTIDE
  申请人：Glytech, Inc.

  公开号：US20140235822A1

  公开（公告）日：2014-08-21

  The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an -SMe group; (b) allowing the -SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b).

  本发明提供了一种生产肽的方法，其特征在于包括将含有—SH基团的氨基酸残基的肽的—SH基团转化为—OH基团，其中所述方法包括以下步骤(a)至(c)：(a)使肽中的—SH基团与甲基化剂反应，将—SH基团转化为-SMe基团；(b)使步骤(a)中获得的-SMe基团与氰化剂反应，产生反应中间体；(c)在比步骤(b)中更基性的条件下将步骤(b)获得的反应中间体转化为含有—OH基团的氨基酸残基的肽。