Chlorocyclopentane;hydron;methoxymethane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Chlorocyclopentane;hydron;methoxymethane
• 英文别名: chlorocyclopentane;hydron;methoxymethane
• 化学式: C7H16ClO+
• 分子量: 151.65
• InChiKey: OQMRHEIRGKGHBT-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.54
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] HETEROCYCLIC COMPOUND<br/>[FR] COMPOSÉ HÉTÉROCYCLIQUE
  申请人：TAKEDA PHARMACEUTICALS CO

  公开号：WO2019027054A1

  公开（公告）日：2019-02-07

  The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

  本发明提供了一种具有HDAC抑制作用的杂环化合物，用于治疗包括神经退行性疾病在内的中枢神经系统疾病，以及包含该化合物的药物。本发明涉及一种由式(I)表示的化合物，其中每个符号如规范中定义的，或其盐。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20210094944A1

  公开（公告）日：2021-04-01

  The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

  本发明提供了一种具有HDAC6抑制作用的杂环化合物，可用于治疗包括神经退行性疾病在内的中枢神经系统疾病，以及包含该化合物的药物。本发明涉及一种由以下式（I）表示的化合物：其中每个符号如描述中定义，或其盐。
• PRODUCTION METHOD OF 1, 2, 4-TRIAZOLE COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20170283383A1

  公开（公告）日：2017-10-05

  A method for producing a 1,2,4-triazole compound involves reacting an amide compound represented by formula (2) with a hydrazide compound represented by formula (3) in a solvent in the presence of a Lewis acid and a Lewis base, thereby obtaining a 1,2,4-triazole compound represented by formula (1): R 1 represents an alkyl group, a cycloalkyl group, an alkoxy group, a cycloalkoxy group, an aryl group, an aryloxy group, a monovalent heterocyclic group or a substituted amino group, R 2 and R 3 each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, a monovalent heterocyclic group or a substituted amino group, and Ring A and Ring B each independently represent an aromatic hydrocarbon ring or an aromatic heterocyclic ring.

  一种制备1,2,4-三唑化合物的方法，涉及在溶剂中，存在Lewis酸和Lewis碱的情况下，将由式（2）表示的酰胺化合物与由式（3）表示的肼化合物反应，从而得到由式（1）表示的1,2,4-三唑化合物：其中，R1表示烷基，环烷基，烷氧基，环烷氧基，芳基，芳氧基，一价杂环基或取代氨基，R2和R3各自独立地表示氢原子，烷基，环烷基，芳基，一价杂环基或取代氨基，环A和环B各自独立地表示芳香族碳环或芳香族杂环。
• LIGHT-EMITTING DEVICE
  申请人：Sumitomo Chemical Company Limited

  公开号：EP3691416A1

  公开（公告）日：2020-08-05

  A light emitting device having an anode, a cathode, a first organic layer and a second organic layer, wherein the first organic layer is a layer containing a metal complex represented by the formula (1), and the second organic layer is a layer containing a metal complex represented by the formula (2) and the like: [M1 represents an iridium atom and the like; n1 represents an integer of 1 or more; n2 represents an integer of 0 or more; Ring R1A represents a triazole ring and the like; Ring R2 represents an aromatic hydrocarbon ring and the like; E1, E2 and E11A to E13A represent a nitrogen atom or a carbon atom; R11A to R13A represent a substituent and the like; A1-G1-A2 represents a bidentate ligand. At least one of E11A to E13A is a nitrogen atom, and at least one of R11A to R13A bonding to the nitrogen atom is a group represented by the formula (Ar-1A).] [Ring A represents an aromatic hydrocarbon ring and the like; R2 represents a substituent and the like.] [M2 represents an iridium atom and the like; n3 represents an integer of 1 or more; n4 represents an integer of 0 or more; EL represents a carbon atom and the like; Ring L1 represents a 6-membered aromatic hetero ring; Ring L2 represents an aromatic hydrocarbon ring and the like; A3-G2-A4 represents a bidentate ligand.].

  一种具有阳极、阴极、第一有机层和第二有机层的发光器件，其中第一有机层是含有由式（1）表示的金属络合物的层，第二有机层是含有由式（2）表示的金属络合物的层等： [M1 代表铱原子等；n1 代表 1 或 1 以上的整数；n2 代表 0 或 0 以上的整数；环 R1A 代表三唑环等；环 R2 代表芳香烃环等；E1、E2 和 E11A 至 E13A 代表氮原子或碳原子；R11A 至 R13A 代表取代基等；A1-G1-A2 代表双齿配体。E11A至E13A中至少有一个是氮原子，与氮原子键合的R11A至R13A中至少有一个是式(Ar-1A)所代表的基团。］ [环 A 代表芳香烃环等；R2 代表取代基等。］ [M2 代表铱原子等；n3 代表 1 或 1 以上的整数；n4 代表 0 或 0 以上的整数；EL 代表碳原子等；环 L1 代表 6 元芳香杂环；环 L2 代表芳香烃环等；A3-G2-A4 代表双齿配体。］
• COMPOSITION AND LIGHT-EMITTING DEVICE USING SAME
  申请人：Sumitomo Chemical Company Limited

  公开号：EP3689887A1

  公开（公告）日：2020-08-05

  A composition comprising a metal complex represented by the formula (1) and a metal complex represented by the formula (2): [wherein, M1 represents an iridium atom and the like; n1 represents an integer of 1 or more; n2 represents an integer of 0 or more; Ring R1A represents a triazole ring and the like; Ring R2 represents an aromatic hydrocarbon ring and the like; R11A to R13A are each a hydrogen atom or a substituent; A1-G1-A2 represents an anionic bidentate ligand. At least one of E11A to E13A is a nitrogen atom, and at least one of R11A to R13A bonding to the nitrogen atom is a group represented by the formula (Ar-1A).] [wherein, Ring A represents an aromatic hydrocarbon ring and the like; R2 represents a substituent.] [wherein, M2 represents an iridium atom and the like; n3 represents an integer of 1 or more; n4 represents an integer of 0 or more; EL represents a carbon atom and the like; Ring L1 represents a 6-membered aromatic hetero ring; Ring L2 represents an aromatic hydrocarbon ring and the like; A3-G2-A4 represents an anionic bidentate ligand. At least one of Ring L1 and Ring L2 has a group represented by the formula (1-T).]         -R1T     (1-T) [wherein, R1T represents a substituent.].

  一种由式（1）代表的金属络合物和式（2）代表的金属络合物组成的组合物： [其中，M1 代表铱原子等；n1 代表 1 或 1 以上的整数；n2 代表 0 或 0 以上的整数；环 R1A 代表三唑环等；环 R2 代表芳香烃环等；R11A 至 R13A 各为氢原子或取代基；A1-G1-A2 代表阴离子双齿配体。E11A至E13A中至少有一个是氮原子，与氮原子键合的R11A至R13A中至少有一个是式(Ar-1A)所代表的基团。］ [其中，环 A 代表芳香烃环等；R2 代表取代基。］ [其中，M2 代表铱原子等；n3 代表 1 或 1 以上的整数；n4 代表 0 或 0 以上的整数；EL 代表碳原子等；环 L1 代表 6 元芳香杂环；环 L2 代表芳香烃环等；A3-G2-A4 代表阴离子双齿配体。环 L1 和环 L2 中至少有一个具有式 (1-T) 所代表的基团。］ -R1T (1-T) [其中，R1T 代表取代基。］