(2R,3S,5S)-4-fluoro-2-(hydroxymethyl)-5-methyloxolan-3-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,5S)-4-fluoro-2-(hydroxymethyl)-5-methyloxolan-3-ol
• 化学式: C₆H₁₁FO₃
• 分子量: 150.15
• InChiKey: YYKPWSPWWHZLTO-DDVDLICKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
  申请人：EMORY UNIVERSITY

  公开号：US20160220595A1

  公开（公告）日：2016-08-04

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

  本公开涉及含有至少一种硫醇、硫酮或硫醚的核苷酸和核苷治疗组合物及其在治疗传染病、病毒感染和癌症方面的用途。
• NGF APTAMER AND APPLICATION THEREOF
  申请人：RIBOMIC INC.

  公开号：US20140235701A1

  公开（公告）日：2014-08-21

  The present invention provides an aptamer binding to NGF and capable of forming a potential secondary structure represented by the formula (I): wherein N is one nucleotide selected from the group consisting of A, G, C, U and T, N11-N13, N21-N23, N32-N38 and N42-N48 are the same or different and each is a bond or 1 or 2 nucleotides selected from the group consisting of A, G, C, U and T, N14, N24, N31, N41, N39 and N49 are the same or different and each is one nucleotide selected from the group consisting of A, G, C, U and T, N14 and N24, N31 and N41, and N39 and N49 each form a Watson-Crick base pair, N11-N12-N13-N14 and N21-N22-N23-N24 are nucleotide sequences capable of forming a stem structure in combination, and N31-N32-N33-N34-N35-N36-N37-N38-N39 and N41-N42-N43-N44-N45-N46-N47-N48-N49 are nucleotide sequences capable of forming a stem structure in combination.
• APTAMER AGAINST MIDKINE AND APPLICATIONS THEREOF
  申请人：RIBOMIC INC.

  公开号：US20150353933A1

  公开（公告）日：2015-12-10

  The present invention provides an aptamer binding to midkine and capable of forming a potential secondary structure represented by the formula (I): wherein X1, X2, X5 and X6 are the same or different and each is one or two nucleotides selected from the group consisting of A, G, C, U and T, or a bond, X1 and X6, and X2 and X5 each form a Watson-Crick base pairs, and X3 and X4 are the same or different and each is a nucleotide selected from A, G, C, U and T.
• US9506070B2
  申请人：——

  公开号：US9506070B2

  公开（公告）日：2016-11-29
• US9567589B2
  申请人：——

  公开号：US9567589B2

  公开（公告）日：2017-02-14