2-fluoro-N-[(4R,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-fluoro-N-[(4R,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• 化学式: C₈H₁₄FNO₆
• 分子量: 239.2
• InChiKey: LMPCEKTVFVQIPT-QUFICUBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20140235575A1

  公开（公告）日：2014-08-21

  The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

  本发明提供了一种一锅多酶法，用于从简单糖起始材料制备UDP糖。该发明还提供了一种一锅多酶法，用于从简单糖起始材料制备寡糖。
• DEPRESSION TREATMENT AGENT
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20170080004A1

  公开（公告）日：2017-03-23

  The invention provides an agent for treating depression, which contains N-acetyl-D-mannosamine, and a pharmaceutical composition for treating depression, which contains an effective amount of N-acetyl-D-mannosamine and a carrier acceptable as a medicament.
• GLUCOSE-SENSITIVE CELL PROTECTING AGENT
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20180085385A1

  公开（公告）日：2018-03-29

  The invention provides an agent containing N-acetyl-D-mannosamine for protecting a glucose-sensitive cell from glucose toxicity due to high glucose concentration; a pharmaceutical composition for protecting a glucose-sensitive cell from glucose toxicity due to high glucose concentration, containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier; use of N-acetyl-D-mannosamine in producing a medicament for protecting a glucose-sensitive cell from glucose toxicity due to high glucose concentration; and a method of protecting a glucose-sensitive cell from glucose toxicity due to high glucose concentration, including administering an effective amount of N-acetyl-D-mannosamine to a subject in need thereof. The glucose-sensitive cell is selected from the group consisting of a nerve cell, a renal cell and a vascular endothelial cell.
• US9290530B2
  申请人：——

  公开号：US9290530B2

  公开（公告）日：2016-03-22
• US9968624B2
  申请人：——

  公开号：US9968624B2

  公开（公告）日：2018-05-15