3-[2-methyl-3-[3-oxo-3-[2-[2-[2-[(2S,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]propoxy]-2-[[3-oxo-3-[2-[2-[2-[(2S,3R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]propoxy]methyl]propoxy]-N-[2-[2-[2-[(2S,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethyl]propanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[2-methyl-3-[3-oxo-3-[2-[2-[2-[(2S,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]propoxy]-2-[[3-oxo-3-[2-[2-[2-[(2S,3R,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethylamino]propoxy]methyl]propoxy]-N-[2-[2-[2-[(2S,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethoxy]ethoxy]ethyl]propanamide
• 化学式: C₅₀H₉₃N₃O₃₀
• 分子量: 1216.3
• InChiKey: FACQWQLKEOAVPD-RDFLVDOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.5
• 重原子数：
  83
• 可旋转键数：
  48
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  469
• 氢给体数：
  15
• 氢受体数：
  30

文献信息

• [EN] COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE<br/>[FR] COMPOSITIONS ET MÉTHODES PERMETTANT D'INHIBER L'EXPRESSION DU GÈNE ALAS1
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2017048843A1

  公开（公告）日：2017-03-23

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.

  该发明涉及针对ALAS1基因的双链核糖核酸(dsRNA)组合物，以及使用这种dsRNA组合物来改变(ALAS1)表达的方法（例如，抑制）。
• SERPINA1 SIRNAS: COMPOSITIONS OF MATTER AND METHODS OF TREATMENT
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：EP2723390B1

  公开（公告）日：2017-12-27
• PCSK9 IRNA COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：EP2929031B1

  公开（公告）日：2017-10-25
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF MYLIP/IDOL GENE<br/>[FR] COMPOSITIONS ET MÉTHODES D'INHIBITION DE L'EXPRESSION DU GÈNE MYLIP/IDOL
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2011091396A1

  公开（公告）日：2011-07-28

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the Mylip/Idol gene, and methods of using such dsRNA compositions to inhibit expression of Mylip/Idol.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'INHIBER L'EXPRESSION DU GÈNE CD274/PD-L1
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2011127180A1

  公开（公告）日：2011-10-13

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L.