(2R,3R,4R)-2-ethoxy-3,4,5-trihydroxypentanal

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4R)-2-ethoxy-3,4,5-trihydroxypentanal
• 化学式: C₇H₁₄O₅
• 分子量: 178.18
• InChiKey: FJIXIWHAWIZRSN-DSYKOEDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NUCLEIC ACID FRAGMENT BINDING TO TARGET PROTEIN
  申请人：RIKEN

  公开号：US20150119254A1

  公开（公告）日：2015-04-30

  An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a DNA aptamer, having higher specificity and binding activity against a target substance than those of nucleic acid aptamers obtained by conventional methods. The present invention provides a transcribable or replicable nucleic acid aptamer comprising a natural nucleotide and a non-natural nucleotide having an artificial base-pairable artificial base. The present invention also provides a method for sequencing a non-natural nucleotide-containing single-stranded nucleic acid molecule selected from a single-stranded nucleic acid library.

  本发明的目的是开发并提供一种有效生产核酸适配体的方法，特别是DNA适配体，其对目标物质具有比传统方法获得的核酸适配体更高的特异性和结合活性。本发明提供了一种可转录或可复制的核酸适配体，其包含一种自然核苷酸和一种非自然核苷酸，后者具有人工可配对人造碱基。本发明还提供了一种从单链核酸库中选择的含有非自然核苷酸的单链核酸分子的测序方法。
• NUCLEIC ACID MOLECULE FOR INHIBITING ACTIVITY OF RNAI MOLECULE
  申请人：Osaka City University

  公开号：EP2781598A1

  公开（公告）日：2014-09-24

  The purpose of the present invention is to develop and provide a nucleic acid molecule that can specifically and efficiently inhibit the activity of a target RNAi molecule and can be produced safely at a low cost. Provided is a nucleic acid molecule for inhibiting the activity of a target RNAi molecule. The nucleic acid molecule comprises a single-stranded nucleic acid moiety that contains one unmodified DNA region composed of a nucleotide sequence completely or sufficiently complementary to a nucleotide sequence of a functional strand having the activity in the target RNAi molecule and a double-stranded nucleic acid moiety to be linked to at least one of the 5'-end and the 3'-end of the single-stranded nucleic acid moiety.

  本发明的目的是开发和提供一种核酸分子，它能特异性地有效抑制目标 RNAi 分子的活性，并能以低成本安全生产。本发明提供了一种用于抑制目标 RNAi 分子活性的核酸分子。该核酸分子包含一个单链核酸分子，该单链核酸分子含有一个未修饰的DNA区域，该DNA区域由与靶RNAi分子中具有活性的功能链的核苷酸序列完全或充分互补的核苷酸序列组成；还包含一个双链核酸分子，该双链核酸分子与单链核酸分子的5'端和3'端中的至少一个相连。
• ACTIVATION OF FUNCTIONAL NUCLEIC ACID BY SPECIFIC MODIFICATION
  申请人：Riken

  公开号：EP2770054A1

  公开（公告）日：2014-08-27

  This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a functional nucleic acid to degradation by nucleolytic enzymes in a simple and cost-effective manner. The single- or double-stranded nucleic acid fragment comprises, ligated to at least one 3' end thereof, a hairpin-shaped DNA comprising: (A) a nucleic acid region consisting of 2 to 5 arbitrary nucleotides; (B) a nucleic acid region consisting of a "gna" or "gnna" base sequence, wherein each "n" represents "g", "t", "a", or "c", a base analogue, or a modified base; and (C) a nucleic acid region consisting of a base sequence complementary to the nucleic acid region (A), sequentially ligated from the 5' end toward the 3' end, wherein at least one of two 3' terminal nucleotides from at least one 3' end of the single-stranded nucleic acid fragment or the double-stranded nucleic acid fragment is modified.

  本发明旨在以简单、经济有效的方式增强和改善单链或双链核酸片段的抗核酸分解能力，该片段包含功能核酸的碱基序列。单链或双链核酸片段包括与至少一个 3'端连接的发夹形 DNA，该 DNA 包括(A) 由 2 至 5 个任意核苷酸组成的核酸区； (B) 由 "gna "或 "gnna "碱基序列组成的核酸区，其中每个 "n "代表 "g"、"t"、"a "或 "c"、碱基类似物或修饰碱基；(C) 由与核酸区（A）互补的碱基序列组成的核酸区，从 5'端向 3'端依次连接，其中单链核酸片段或双链核酸片段的至少一个 3'端的两个 3'端核苷酸中至少有一个被修饰。
• US20140256794A1
  申请人：——

  公开号：US20140256794A1

  公开（公告）日：2014-09-11
• US9540650B2
  申请人：——

  公开号：US9540650B2

  公开（公告）日：2017-01-10