7-[3-[6-methoxy-4-[(2-methyl-1H-indol-5-yl)oxy]quinazolin-7-yl]oxypropyl]-2-oxa-7-azaspiro[3.5]nonane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-[3-[6-methoxy-4-[(2-methyl-1H-indol-5-yl)oxy]quinazolin-7-yl]oxypropyl]-2-oxa-7-azaspiro[3.5]nonane
• 化学式: C₂₈H₃₂N₄O₄
• 分子量: 488.6
• InChiKey: PRUNJNYNAZJGOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US20140235657A1

  公开（公告）日：2014-08-21

  Described herein are compounds of Formula (I)-(III), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating and/or preventing diseases are also provided.

  本文描述了公式(I)-(III)的化合物，其药学上可接受的盐以及其制药组合物。还提供了包含公式(I)-(III)化合物和制药组合物的颗粒（例如，纳米颗粒），这些颗粒具有穿透黏液的特性。还提供了使用这些化合物或制药组合物治疗和/或预防疾病的方法。
• Therapeutic compounds and uses thereof
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US10285991B2

  公开（公告）日：2019-05-14

  Described herein are compounds of Formula (I)-(III), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating and/or preventing diseases are also provided.

  本文描述了式 (I)-(III) 化合物、其药学上可接受的盐及其药物组合物。还提供了由式（I）-（III）化合物及其药物组合物组成的具有粘液渗透性的颗粒（如纳米颗粒）。还提供了使用这些化合物或其药物组合物治疗和/或预防疾病的方法。
• US9353123B2
  申请人：——

  公开号：US9353123B2

  公开（公告）日：2016-05-31
• US9833453B2
  申请人：——

  公开号：US9833453B2

  公开（公告）日：2017-12-05
• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：KALA PHARMACEUTICALS INC

  公开号：WO2014130612A1

  公开（公告）日：2014-08-28

  Described herein are compounds of Formula (I)-(III), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating and/or preventing diseases are also provided.