4-[4-[(4-chloro-3-methylphenyl)carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[4-[(4-chloro-3-methylphenyl)carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid
• 化学式: C28H27ClN4O6S
• 分子量: 583.1
• InChiKey: YDSZPUBXCSKAIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.08
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• DNA hypomethylating agents for cancer therapy
  申请人：Maio Michele

  公开号：US11083743B2

  公开（公告）日：2021-08-10

  The present invention relates to a method of treating and/or preventing cancer comprising administering a combination of an effective amount of a DNA hypomethylating agent and an effective amount of at least one immunomodulatory agent and/or optionally an effective amount of at least one targeted therapy agent.

  本发明涉及一种治疗和/或预防癌症的方法，包括施用有效量的 DNA 低甲基化剂和有效量的至少一种免疫调节剂和/或有效量的至少一种靶向治疗剂的组合。
• DNA HYPOMETHYLATING AGENTS FOR CANCER THERAPY
  申请人：Maio, Michele

  公开号：EP2958571A1

  公开（公告）日：2015-12-30
• [EN] DNA HYPOMETHYLATING AGENTS FOR CANCER THERAPY<br/>[FR] AGENTS D'HYPOMÉTHYLATION DE L'ADN POUR THÉRAPIE ANTICANCÉREUSE
  申请人：MAIO MICHELE

  公开号：WO2014128245A1

  公开（公告）日：2014-08-28

  The present invention relates to a method of treating and/or preventing cancer comprising administering a combination of an effective amount of a DNA hypomethylating agent and an effective amount of at least one immunomodulatory agent and/or optionally an effective amount of at least one targeted therapy agent.