hydron;(2R,3R,4R,5S)-6-(methylaminooxy)hexane-1,2,3,4,5-pentol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: hydron;(2R,3R,4R,5S)-6-(methylaminooxy)hexane-1,2,3,4,5-pentol
• 化学式: C7H19NO6+2
• 分子量: 213.23
• InChiKey: HQEQWDJZDJYUQA-XZBKPIIZSA-P

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  122
• 氢给体数：
  8
• 氢受体数：
  7

文献信息

• METHODS FOR EVALUATING BRAIN-WIDE PARAVASCULAR PATHWAY FOR WASTE CLEARANCE FUNCTION AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS BASED THEREON
  申请人：University Of Rochester

  公开号：EP2964270A1

  公开（公告）日：2016-01-13
• [EN] METHODS FOR EVALUATING BRAIN-WIDE PARAVASCULAR PATHWAY FOR WASTE CLEARANCE FUNCTION AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS BASED THEREON<br/>[FR] PROCÉDÉS D'ÉVALUATION DE LA VOIE PARAVASCULAIRE CÉRÉBRALE POUR LA FONCTION D'ÉLIMINATION DES DÉCHETS ET PROCÉDÉS DE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS ASSOCIÉS
  申请人：UNIV ROCHESTER

  公开号：WO2014130777A1

  公开（公告）日：2014-08-28

  Methods are provided for measuring glio-vascular pathway ("glymphatic system") function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid - interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.