(3S,5S)-6-(hydroxymethyl)-3-methyloxane-2,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,5S)-6-(hydroxymethyl)-3-methyloxane-2,4,5-triol
• 化学式: C₇H₁₄O₅
• 分子量: 178.18
• InChiKey: YVJXTNFYGMZWPR-UXEHOLJYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• SYNTHETIC DERIVATIVES OF MPL AND USES THEREOF
  申请人：VARIATION BIOTECHNOLOGIES INC.

  公开号：US20140328876A1

  公开（公告）日：2014-11-06

  In one aspect, the present disclosure provides compounds of formulae (I) and (II). In another aspect, a compound of formula (I) or (II) is formulated into compositions with an antigen, optionally with a vesicle. In some embodiments, compositions are administered intramuscularly.

  在一个方面，本公开提供了式(I)和(II)的化合物。在另一个方面，将式(I)或(II)的化合物与抗原配制成组合物，可选地与囊泡一起。在一些实施方式中，这些组合物是肌肉注射给药的。
• GLYCOSYLATED ANTITUMOR ETHER LIPIDS AS NOVEL CANCER STEM CELL CYTOTOXIC AGENTS
  申请人：UNIVERSITY OF MANITOBA

  公开号：US20150011486A1

  公开（公告）日：2015-01-08

  Glycosylated antitumor ether lipids (GAELs) are effective cytotoxic agents against cancer stem cells. Furthermore, combining GAELs which kill cells by a caspase-independent pathway with agents that kill cells by apoptosis will lead to elimination of the differentiated tumor cells and the undifferentiated cancer stem cells leading to an elimination of the tumor and preventing recurrence.

  糖基化抗肿瘤醚类脂质（GAELs）是有效的细胞毒性剂，可针对癌症干细胞。此外，将能够通过非半胱氨酸依赖途径杀死细胞的GAELs与能够通过凋亡杀死细胞的药物结合使用，将导致消除分化的肿瘤细胞和未分化的癌症干细胞，从而消除肿瘤并防止复发。
• GLYCOCONJUGATES AND USE THEREOF AS VACCINE AGAINST SHIGELLA FLEXNERI SEROTYPE 3a AND X
  申请人：INSTITUT PASTEUR

  公开号：US20150050282A1

  公开（公告）日：2015-02-19

  The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.

  本发明涉及从糖衍生物中复制Shigella flexneri 3a和X血清型表位的化合物，以及用于制备疫苗组分的使用方法。更具体地说，本发明的主题涉及新型糖连接化合物，包括下文描述的寡糖或多糖，以及合成这些寡糖或多糖和糖连接物的方法，这些寡糖或多糖的衍生物，含有它们的组合物，以及将糖连接物用于疫苗接种目的的用途。最后，本发明涉及使用一种或多种寡糖或多糖或其共轭物来诊断Shigella flexneri感染的方法。
• THIOSACCHARIDE MUCOLYTIC AGENTS
  申请人：The Regents of The University of California

  公开号：US20160060284A1

  公开（公告）日：2016-03-03

  There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.

  本文提供了一些方法，用于降低需要的受试者的黏液弹性或黏液粘度，其中方法包括向受试者施用有效量的硫代糖黏液溶解剂，以及用于该方法的化合物和制药组合物。
• PREPARATION OF PNA-6-AMINOGLUCOSAMINE CONJUGATES AS ANTIVIRAL AGENTS
  申请人：Rutgers, The State University of New Jersey

  公开号：US20140371137A1

  公开（公告）日：2014-12-18

  The present invention relates to methods and compositions pertaining to conjugates comprising a nucleic acid oligomer conjugated to a glucosamine or a derivative thereof which are useful for inhibiting the transcription of target nucleic acids. The conjugates of the invention exhibit advantageous bioavailability and readily penetrate cell membranes which make them useful for inhibiting translation of target mRNA in vivo.