(2S,3R,4S,5S,6S)-6-[(Z)-1-hydroxyprop-1-enyl]oxane-2,3,4,5-tetrol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,5S,6S)-6-[(Z)-1-hydroxyprop-1-enyl]oxane-2,3,4,5-tetrol
• 化学式: C₈H₁₄O₆
• 分子量: 206.19
• InChiKey: IWGSAFVUIPJTDE-QYQUHBHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS RELATING TO INDUCTION OF INTESTINAL STEM CELL HOMEOGENESIS AND/OR REGENERATION<br/>[FR] COMPOSITIONS ET MÉTHODES ASSOCIÉES À L'INDUCTION DE L'HOMOGENÈSE ET/OU DE LA RÉGÉNÉRATION DE CELLULES SOUCHES INTESTINALES
  申请人：UNIV MICHIGAN

  公开号：WO2014134038A1

  公开（公告）日：2014-09-04

  The present invention relates to compositions and methods for inducing intestinal stem cell homeogenesis and/or regeneration within intestinal tissue expressing Robo1 through administration of a Rspo1 agent and a Slit2 agent. Administration of such agents results in, for example, binding of the Rspo1 agent and Slit2 agent with Robo1, resulting in, for example, binding of the CC3 motif of Robo1 with LRP6, resulting in phosphorylation of LRP6, and ultimately, induction of intestinal stem cell homeogenesis and/or regeneration. In certain embodiments, such administration of a Rspo1 agent and a Slit2 agent is used to protect and/or prevent intestinal tissue damage resulting from exposure to an intestinal tissue damaging event (e.g., radiation). The agents and related compositions additionally find use in diagnostic and research settings.