2-(2-Aminoethyl)cyclopent-4-ene-1,3-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-Aminoethyl)cyclopent-4-ene-1,3-dione
• 英文别名: 2-(2-aminoethyl)cyclopent-4-ene-1,3-dione
• 化学式: C₇H₉NO₂
• 分子量: 139.15
• InChiKey: WYIWDXYZPPZAGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS
  申请人：IMMUNOGEN, INC.

  公开号：US20150359904A1

  公开（公告）日：2015-12-17

  The invention provides linker compounds and cytotoxic compounds that are useful for forming a CBA-drug conjugates; and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.
• ANTI-CD123 ANTIBODIES AND CONJUGATES AND DERIVATIVES THEREOF
  申请人：ImmunoGen, Inc.

  公开号：US20170029514A1

  公开（公告）日：2017-02-02

  The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.
• [EN] CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS COMPRENANT DES AGENTS DE LIAISON CELLULAIRE (CBA) ET DES AGENTS CYTOTOXIQUES
  申请人：IMMUNOGEN INC

  公开号：WO2014134486A2

  公开（公告）日：2014-09-04

  The invention provides linker compounds and cytotoxic compounds that are useful for forming a CBA-drug conjugates; and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.